Nucleic acid aptamer application in diagnosis and therapy of colorectal cancer based on cell-SELEX technology
نویسندگان
چکیده
منابع مشابه
Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy
SELEX (systematic evolution of ligands by exponential enrichment) is a process involving the progressive isolation of high selective ssDNA/RNA from a combinatorial single-stranded oligonucleotide library through repeated rounds of binding, partitioning and amplification. SELEX-derived single-stranded DNA/RNA molecules, called aptamers, are selected against a wide range of targets, including pur...
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متن کاملNucleic acid aptamers in cancer research, diagnosis and therapy.
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence pool, with the ability to form unique and versatile tertiary structures that bind to cognate molecules with superior specificity. Their small size, excellent chemical stability and low immunogenicity enable them to rival antibodies in cancer imaging and therapy applications. Their facile chemical synthesis, ver...
متن کاملRecent Advances in SELEX Technology and Aptamer Applications in Biomedicine
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Thanks to the inherit merits, aptamers have been used in a wide range of applications, including disease diagnosis, targeted delivery agents and therapeutic uses. To...
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ژورنال
عنوان ژورنال: npj Precision Oncology
سال: 2017
ISSN: 2397-768X
DOI: 10.1038/s41698-017-0041-y